INTRAVENOUS AND SUBCUTANEOUS TOXICITY AND ABSORPTION KINETICS IN MICE AND DOGS OF THE ANTILEISHMANIAL TRITERPENE SAPONIN PX-6518

Intravenous and Subcutaneous Toxicity and Absorption Kinetics in Mice and Dogs of the Antileishmanial Triterpene Saponin PX-6518

The intravenous (IV) and subcutaneous (SC) toxicity and absorption kinetics of the antileishmanial triterpene saponin PX-6518 and its active constituents maesabalide-III and -IV were studied in mice and dogs.A high-dose wash-out study of PX-6518 at 20 mg/kg SC for 5 days and a single low-dose wash-out study at 1, 2.5 or 5 mg/kg SC and IV with follo

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Alcalase-Based Chickpea (Cicer arietinum L.) Protein Hydrolysates Efficiently Reduce Systolic Blood Pressure in Spontaneously Hypertensive Rats

Studies Feutre Synthetic on antihypertensive chickpea protein hydrolysates have rarely performed in vivo evaluations, limiting the entry of such hydrolysates into functional food development and clinical trials.Thus, our aim was to optimize the hydrolysis conditions to produce an alcalase-based chickpea hydrolysate with a hypotensive effect in vivo

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Peatland water conservation by agroforestry system

Peat swamp forest have a high economic value and are potential for agricultural development.However, peatlad are fragile ecosystems because they are easily damaged and difficult to restore.The main problem of all peat soil types is their irreversible drying.In this condition the peat soil is easy burning, unable to store water, and if the groundwat

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